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dc.contributor.authorSalvia, William S.
dc.contributor.authorMantel, Georgia
dc.contributor.authorSaha, Nirob K.
dc.contributor.authorRajawasam, Chamoni W. H.
dc.contributor.authorKonkolewicz, Dominik
dc.contributor.authorHartley, C. Scott
dc.date.accessioned2024-04-25T13:13:53Z
dc.date.available2024-04-25T13:13:53Z
dc.identifier.urihttp://hdl.handle.net/2374.MIA/6979
dc.description.abstractCarbodiimide-driven anhydride formation from carboxylic acids is useful in a variety of non-equilibrium systems. While multiple strategies to control deactivation rates (anhydride hydrolysis) have been reported, control over activation rates (anhydride formation) is currently limited. We show that pyridines reversibly form adducts with 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide methiodide in water. These adducts are unreactive with carboxylic acids and thus reduce the anhydride formation rate while prolonging carbodiimide lifetime. The best results are obtained with 4-methoxypyridine. This strategy can be used to control the formation of transient polymer network hydrogels, in one example increasing the time to reach peak modulus by 86% and the lifetime by 43%.en_US
dc.rightsAttribution-NonCommercial 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/us/*
dc.titleData archive for "Controlling Carbodiimide-Driven Reaction Networks Through the Reversible Formation of Pyridine Adducts"en_US
dc.typeJournal Articleen_US
dc.date.published2024


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  • Hartley, Scott
    Dr. Scott Hartley - Professor, Chemistry & Biochemistry

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Attribution-NonCommercial 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial 3.0 United States